郑颖丰
专业：眼科学
职称：研究员
研究方向：1.眼科流行病学和临床研究
2.眼炎症/免疫性疾病的发病机制和靶向干预研究
3.视觉发生与视网膜神经生物学研究
简介
研究员，博士生导师，在Nature Communications、PNAS和Communications Biology等期刊发表通讯/共同通讯SCI文章。论文总被引30078次、H-指数55。全球前2%顶尖科学家2023榜单的眼科及眼视光领域排名第3。
代表性论著
- Wen Shi; Jinguo Ye; Zhuoxing Shi; Caineng Pan; Qikai Zhang; Yuheng Lin; Dan Liang; Yizhi Liu; Xianchai Lin; Yingfeng Zheng; Single-cell chromatin accessibility and transcriptomic characterization of Behcet’s disease, Communications Biology, 2023, 6(1): 1048 (最后通讯作者)
- Zhao-Jing Lu; Jin-Guo Ye; Dong-Liang Wang; Meng-Ke Li; Qi-Kai Zhang; Zhong Liu; Yan-Jing Huang; Cai-Neng Pan; Yu-Heng Lin; Zhuo-Xing Shi; Ying-Feng Zheng; Integrative single-cell RNA Seq and ATAC-Seq analysis of mouse corneal epithelial cells, Investigative Opthalmology & Visual Science, 2023, 64(3): 30 (最后通讯作者)
- Guilan Li; Yuanting Luo; Qikai Zhang; Wenfei Chen; Kunbei Lai; Yizhi Liu; Yingfeng Zheng; The RBPMSCreERT2-tdTomato mouse line for study retinal and vascular relevant diseases, iScience, 2023, 26(11): 108111 (唯一通讯作者)
- Wen Shi; Jinguo Ye; Zhuoxing Shi; Caineng Pan; Qikai Zhang; Yuheng Lin; Yuanting Luo; Wenru Su; Yingfeng Zheng; Yizhi Liu ; Chromatin accessibility analysis reveals regulatory dynamics and therapeutic relevance of Vogt-Koyanagi-Harada disease, Communications biology, 2022, 5(1): 506 (唯一通讯作者)
- Zhong Liu; Yanjing Huang; Dongliang Wang; Mengke Li; Qikai Zhang; Caineng Pan; Yuheng Lin; Yuanting Luo; Zhuoxing Shi; Ping Zhang; Yingfeng Zheng; Insights gained from single-cell RNA analysis of murine endothelial cells in aging hearts, Heliyon, 2023, 9(8): e18324 (最后通讯作者)
代表性成果
1）开发单细胞CyTOF测序技术平台，揭示人群外周血免疫单细胞转录和蛋白图谱；
2）利用单细胞RNA-seq测序技术，发现PIM1激酶是葡萄膜炎的重要调控因子及治疗新靶点；
3）利用单细胞ATAC-seq测序技术，揭示小柳原田综合征患者外周免疫细胞转录动态特征；
4）揭示性别与衰老因素对人体外周血免疫单细胞转录调控的影响；
5）揭示熬夜行为增加自身免疫性疾病、肿瘤和感染风险的分子机制。
